Overexpression of CDR1 and CDR2 Genes Plays an Important Role in Fluconazole Resistance in Candida albicans with G487T and T916C Mutations
نویسندگان
چکیده
منابع مشابه
Using PCR to Compare the Expression of CDR1, CDR2, and MDR1 in Candida Albicans Isolates Resistant and Susceptible to Fluconazole
Abstract Background and objectives: More Candida albicans strains are reported resistant to fluconazole in patients with AIDS, cancer and organ recipients. Fluconazole resistance can be attributed to changes in pathways of sterol biosynthesis, mutation in or overexpression of ERG11 and the expression of CDR1, CDR2, and MDR1. This study aimed to compare the ex...
متن کاملOverexpression of MDR-1 and CDR-2 genes in fluconazole resistance of Candida albicans isolated from patients with vulvovaginal candidiasis
Background and Purpose: Candida albicans (C. albicans) is an opportunistic fungus that can colonize women’s mucosal epithelial cell surfaces, causing vulvovaginitis in specific circumstances. The major genes contributing to drug resistance in C. albicans are the candida drug resistance (CDR) and multi drug resistance (MDR) genes. The purpose of this study was to evaluate the CDR-2 and MDR...
متن کاملOverexpression of Candida albicans CDR1, CDR2, or MDR1 does not produce significant changes in echinocandin susceptibility.
The micafungin and caspofungin susceptibilities of Candida albicans laboratory and clinical isolates and of Saccharomyces cerevisiae strains stably hyperexpressing fungal ATP-binding cassette (ABC) or major facilitator superfamily (MFS) transporters involved in azole resistance were determined using three separate methods. Yeast strains hyperexpressing individual alleles of ABC transporters or ...
متن کاملRegulated overexpression of CDR1 in Candida albicans confers multidrug resistance.
OBJECTIVES Information on the function of Candida albicans ATP-binding cassette (ABC) membrane transporter Cdr1p has come from studying the effect of gene inactivation in C. albicans and from heterologous Cdr1p expression in the yeast Saccharomyces cerevisiae. These approaches, however, give only an indirect indication of Cdr1p function in C. albicans itself. The objective of this study was to ...
متن کاملRelation of ALS 1 and ALS3 genes and fluconazole resistance in Candida albicans isolated from vaginal candidacies
Candida albicans is an opportunistic fungi that is able to thrive in many host niches, including the skin, mucosal, surfaces, the blood stream and internal organs. Agglutinin-like sequence (ALS) genes which could play a role in forming biofilms, adherence to host surfaces as a virulence factor and antifungal drug resistant. The purpose of the present study was to evaluate the presence ALS1 and ...
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ژورنال
عنوان ژورنال: Journal of International Medical Research
سال: 2010
ISSN: 0300-0605,1473-2300
DOI: 10.1177/147323001003800216